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1.
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15 p, 3.6 MB |
Red Blood Cells and Endothelium Derived Circulating Extracellular Vesicles in Health and Chronic Heart Failure : A Focus on Phosphatidylserine Dynamics in Vesiculation
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Suades, Rosa (Institut d'Investigació Biomèdica Sant Pau) ;
Vilella-Figuerola, Alba (Institut d'Investigació Biomèdica Sant Pau) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Mirabet Pérez, Sonia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Circulating extracellular microvesicles (cEVs) are characterised by presenting surface antigens of parental cells. Since their biogenesis involves the translocation of phosphatidylserine (PS) from the inner to the outer leaflet of the plasma membrane, exposed PS has been considered as a recognition hallmark of cEVs. [...]
2023 -  10.3390/ijms241411824
International journal of molecular sciences, Vol. 24, Num. 14 (july 2023)
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3.
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14 p, 1.6 MB |
Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy
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Arqueros, Cristina (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gallardo, Alberto (Institut de Recerca Sant Pau) ;
Vidal, Silvia (Institut de Recerca Sant Pau) ;
Osuna Gómez, Rubén (Institut de Recerca Sant Pau) ;
Tibau Martorell, Ariadna (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Bell, Olga (Institut de Recerca Sant Pau) ;
Ramon y Cajal, Teresa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Lerma Puertas, Enrique (Institut de Recerca Sant Pau) ;
Lobato-Delgado, Bárbara (Institut de Recerca Sant Pau) ;
Salazar, Juliana (Institut de Recerca Sant Pau) ;
Barnadas i Molins, Agustí (Institut de Recerca Sant Pau) ;
Universitat Autònoma de Barcelona
Currently, therapy response cannot be accurately predicted in HER2-negative breast cancer (BC). Measuring stromal tumour-infiltrating lymphocytes (sTILs) and mediators of the tumour microenvironment and characterizing tumour-infiltrating immune cells (TIICs) may improve treatment response in the neoadjuvant setting. [...]
2024 - 10.3390/ijms25052627
International journal of molecular sciences, Vol. 25 (february 2024)
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4.
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15 p, 5.7 MB |
Small Non-Coding RNAs and Their Role in Locoregional Metastasis and Outcomes in Early-Stage Breast Cancer Patients
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Escuin i Borràs, Daniel (Institut de Recerca Sant Pau) ;
Bell, Olga (Institut de Recerca Sant Pau) ;
García-Valdecasas Vilanova, Bárbara (Institut de Recerca Sant Pau) ;
Clos Enríquez, Montserrat (Institut de Recerca Sant Pau) ;
Larrañaga, Itziar (Institut de Recerca Sant Pau) ;
López Vilaró, Laura (Institut de Recerca Sant Pau) ;
Mora, Josefina (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Andrés, Marta (Institut de Recerca Sant Pau) ;
Arqueros, Cristina (Institut de Recerca Sant Pau) ;
Barnadas i Molins, Agustí (Institut de Recerca Sant Pau) ;
Universitat Autònoma de Barcelona
Deregulation of small non-coding RNAs (sncRNAs) has been associated with the onset of metastasis. We evaluated the expression of sncRNAs in patients with early-stage breast cancer, performing RNA sequencing in 60 patients for whom tumor and sentinel lymph node (SLN) samples were available, and conducting differential expression, gene ontology, enrichment and survival analyses. [...]
2024 - 10.3390/ijms25073982
International journal of molecular sciences, Vol. 25 (april 2024)
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5.
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18 p, 2.0 MB |
Persistence of Chronic Lymphocytic Leukemia Stem-like Populations under Simultaneous In Vitro Treatment with Curcumin, Fludarabine, and Ibrutinib : Implications for Therapy Resistance
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Bistué Rovira, Àngel (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
G. Rico, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bardina, Jorge (Vall d'Hebron Institut d'Oncologia) ;
Junca, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bradford, Jolene A. (Thermo Fisher Scientific (Estats Units d'Amèrica)) ;
Ward, Michael D. (Thermo Fisher Scientific (Estats Units d'Amèrica)) ;
Salvia, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Petriz, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Leukemic stem cells (LSCs) possess similar characteristics to normal hematopoietic stem cells, including self-renewal capacity, quiescence, ability to initiate leukemia, and drug resistance. These cells play a significant role in leukemia relapse, persisting even after apparent remission. [...]
2024 - 10.3390/ijms25041994
International journal of molecular sciences, Vol. 25, Num. 4 (february 2024)
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16 p, 5.9 MB |
Adipokines as New Biomarkers of Immune Recovery : Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy
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Yeregui, Elena (Instituto de Salud Carlos III) ;
Masip, J. (Instituto de Salud Carlos III) ;
Viladés, C. (Instituto de Salud Carlos III) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Pacheco, Y.M. (Universidad de Sevilla) ;
Blanco, J. (Universitat de Vic - Universitat Central de Catalunya) ;
Mallolas Masferrer, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alba, Verónica (Instituto de Salud Carlos III) ;
Vargas, M. (Instituto de Salud Carlos III) ;
García-Pardo, G. (Instituto de Salud Carlos III) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Olona, M. (Instituto de Salud Carlos III) ;
Vidal-González, J. (Universitat de Barcelona) ;
Peraire, M. (Universitat Rovira i Virgili) ;
Martí, A. (Instituto de Salud Carlos III) ;
Reverté, L. (Instituto de Salud Carlos III) ;
Gómez-Bertomeu, F. (Instituto de Salud Carlos III) ;
Leal, M. (Hospital Viamed Santa Ángela de la Cruz) ;
Vidal, F. (Instituto de Salud Carlos III) ;
Peraire, J. (Instituto de Salud Carlos III) ;
Rull, A. (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4 T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. [...]
2022 - 10.3390/ijms23042202
International journal of molecular sciences, Vol. 23 Núm. 4 (2-2 2022) , p. 2202
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17 p, 3.9 MB |
Hypercholesterolemia-Induced HDL Dysfunction Can Be Reversed : The Impact of Diet and Statin Treatment in a Preclinical Animal Model
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Schoch, Leonie (Institut d'Investigació Biomèdica Sant Pau) ;
Sutelman, P. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Suades, Rosa (Institut d'Investigació Biomèdica Sant Pau) ;
Casani, L. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
High-density lipoproteins (HDL) undergo adverse remodeling and loss of function in the presence of comorbidities. We assessed the potential of lipid-lowering approaches (diet and rosuvastatin) to rescue hypercholesterolemia-induced HDL dysfunction. [...]
2022 - 10.3390/ijms23158596
International journal of molecular sciences, Vol. 23 Núm. 15 (august 2022) , p. 8596
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25 p, 6.8 MB |
Role of Ion Channels in the Maintenance of Sperm Motility and Swimming Behavior in a Marine Teleost
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Castro-Arnau, Júlia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Chauvigné, François (Institut de Ciències del Mar) ;
Cerdà, Joan (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
In oviparous marine fishes, the hyperosmotic induction of sperm motility in seawater (SW) is well established, however, the potential function of ion channels in the maintenance of post activated spermatozoon swimming performance remains largely unknown. [...]
2022 - 10.3390/ijms232012113
International journal of molecular sciences, Vol. 23, Issue 20 (October 2022) , art. 12113
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19 p, 2.4 MB |
Global Impairment of Immediate-Early Genes Expression in Rett Syndrome Models and Patients Linked to Myelination Defects
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Petazzi, Paolo (Instituto de Salud Carlos III) ;
Jorge-Torres, Olga Caridad (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gomez, Antonio (Universitat de Vic - Universitat Central de Catalunya) ;
Scognamiglio, Iolanda (Institut d'Investigació Biomèdica de Bellvitge) ;
Serra-Musach, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ;
Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Grases, Daniela (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Xiol, Clara (Hospital Sant Joan de Déu (Manresa)) ;
O'Callaghan, Maria del Mar (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Armstrong, Judith (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Rett syndrome (RTT) is a severe neurodevelopmental disease caused almost exclusively by mutations to the MeCP2 gene. This disease may be regarded as a synaptopathy, with impairments affecting synaptic plasticity, inhibitory and excitatory transmission and network excitability. [...]
2023 - 10.3390/ijms24021453
International journal of molecular sciences, Vol. 24 Núm. 2 (january 2023)
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